Paracetamol is an anti‐inflammatory analgesic agent indicated for acute and chronic treatment of rheumatoid arthritis. Paracetamol is poorly water soluble and may show dissolution limited absorption. Here,solid dispersion(SDs) of paracetamol with diff. Carrier (PEG 4000, PEG 6000, β-cyclodextrine) by the physical mixing method, kneading method and solvent evaporation method were prepared using 1:2, 1:4 and 1:6 ratio. The SDs was characterized in physical appearance, solubility, Drug content, IR, and in vitro dissolution studies. Solubility of paracetamol from SDs increased in distilled water. The drug content was found to be high and uniformly distributed in the all formulations. The prepared dispersion showed a marked increase in the dissolution rate of paracetamol than that of pure drugs. The dispersion with β-cyclodextrine (1:6) by kneading method (F24) showed faster dissolution rate (100.98%) as compared to other dispersions. The dissolution of the Paracetamol could be improved by solid dispersion technique may be due to increase wettability and hydrophilic nature of carriers.
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